Formulation and evaluation of floating beads of esomeprazole magnesium USP

Maria Stanley, Tania; Raj R, Praveen; P.A, Daisy

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DOI 10.18231/j.ijpca.2019.007
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Formulation and evaluation of floating beads of esomeprazole magnesium USP

Author Details:

Tania Maria Stanley

Praveen Raj R

Daisy P.A ^*

International Journal of Pharmaceutical Chemistry and Analysis. 6(2):40-43, 2019. | 10.18231/j.ijpca.2019.007

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The aim of this study was to develop and evaluate floating beads of Esomrazole Magnesium USP. Floating beads of Esomeprazole was prepared by ionotropic gelatin method using sodium alginate as the polymer. Five different formulations were developed. The developed floating beads were evaluated for percentage yield, particle size, in vitro buoyancy, scanning electron microscopy and drug release. Stability studies were carried for 45 days. There are no significant change in the drug entrapment, buoyancy, and drug release of floating beads Esomeprazole Magnesium after 45 days. The polymer used was Sodium alginate. FTIR study results showed that there were no incompatibility between drug and polymer. Solubility study was performed and recorded the results. Results of our present study suggest that floating beads of Esomeprazole Magnesium can be successfully designed for controlled drug delivery which can reduce dosing frequency making the formulation an effective alternative to conventional dosage forms.

Keywords: Floating beads, Esomeprazole magnesium, Buoyancy, In vitro.

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International Journal of Pharmaceutical Chemistry and Analysis

Formulation and evaluation of floating beads of esomeprazole magnesium USP

Author Details: Tania Maria Stanley Praveen Raj R Daisy P.A *

References

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Author Details:

Tania Maria Stanley

Praveen Raj R

Daisy P.A ^*