Antidepressant Activity of Some Novel 1, 2, 4 Triazole Substituted Quinazoline Derivatives

• Author Details:   
• Narendra Joshi
• Anju Goyal

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Introduction: Quinazoline is an important moiety found natural and used for their biological activity, quinazoline always attract scientist due to its broad therapeutic value. In the present research article we prepared a series of fifteen compound by conjugating to prominent therapeutic active moiety to produce synergistic effect to mimic the antidepressant activity of quinazoline.
Methods: In the process firstly we synthesized substituted 1, 2, 4-triazole and added to the benzoxazine moiety to synthesized derivatives of quinazolines. all the synthesized compound was screened for antidepressant activity by using The Porsolt forced swimming test, The synthesized compounds (20 mg/kg), imipramine (20 mg/kg), and Fluoxetine (20 mg/kg) suspended in aqueous tween 80 (0.5%), were injected as intraperitoneally (i p) and the mouse forced to swim in water cylinder and the vigorous activity observed.
Result: From the synthesized compound Qazo7, Qazo9 and Qazo11 show prominent activity the duration of Immobility is 29.6±0.80, 29.5±1.41 and 29.5±0.62 respectively, compare to standard Fluoxetine and Imipramine.
Conclusion: It can be stated that combination of quinazoline with triazole provide effective antidepressant activity, the synthesized compound may be help to develop potent and safe antidepressant moiety.

Keywords: Quinazoline, Triazole, Antidepressant, Imipramine, Forced swim method