Formulation, Optimization and Characterization of Gastro-rententive Troxipide Microspheres

• Author Details:   
• Manisha Karpe
• Monika Kumbhar
• Ravindra Tupe
• Gaurav Bhamare
• Vilasrao Kadam

---

View PDF

Troxipide -loaded gastro retentive floating microspheres using Ethylcellulose as matrix and methanol as mucoadhesive polymer were prepared for the purpose of improving sustain drug release for about 12h of troxipide to produce local action and reduce dose frequency. The morphological properties of the microspheres were studied by optical microscopy and scanning electron microscopy (SEM). Floating microspheres are gaining attention due to their wide applicability in the targeting of drugs to the stomach. These floating microspheres have the advantage they remain buoyant and distributed uniformly over the gastric fluid to avoid the vagaries of gastric emptying and release the drug for prolonged periods of time. Multi-particulates low-density partices can successfully prolong the gastric retention time of the drugs. This article can provide an overview of two important approaches utilized to prepare and improve the performance of floating microspheres.

Keywords:  GRDFs, FDDS, Hollow Microspheres, Troxipide, Sustain release, Local actions