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Validated spectrophotometric method for simultaneous estimation of rosuvastatin calcium and aspirin in tablet dosage forms
- Author Details:
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Gandla Kumaraswamy
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Repeudi Lalitha
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K. Vijayaprakash
The present work was aimed at method development and validation for simultaneous estimation of Rosuvastatin Calcium and Aspirin by UV-Spectrophotometric method in pharmaceutical dosage form. In UV method 0.1N NaoH as solvent and ?max of Rosuvastatin Calcium and Aspirin were found to be 232 nm and 222 nm respectively. Concentration ranges were found to be 4-20µg/mL for both drugs. The R2 values were found to be 0.996 and 0.999 for Rosuvastatin Calcium and Aspirin respectively. The method was validated statistically and by recovery studies. Percentage Assay and Recovery were found to be 95-105% for Rosuvastatin Calcium and Aspirin. LOD and LOQ ranges were found to be 0.177 and 0.539µg/mL and 0.298 and 0.903µg/mL for Rosuvastatin Calcium and Aspirin respectively. This method was validated using ICH guidelines.
Key words: Aspirin, Rosuvastatin, UV-Spectrophotometric method, Simultaneous equation, Validation
References
- United States Pharmacopoeia national formulatory. 2008, P.No. 3156,2334.
- Indian Pharmacopoeia ministry of health and family welfare, Governent of India, New Delhi, 2007, Vol 2, P.No. 151,159,318,1194,1648.
- Martindale 35 th edition, The complete drug reference, P.No. 1266.3.
- Merk index, 14 th edition, 2003, P.No. 5938.
- Popat B. Mhite, ASPdas. B, Spectrophotometric simultaneous determination of Rosuvastatin and Aspirin in combined tablet dosage form, Oriental J. of Chemistry., 2009, V-25(1), P.No.137-141.
- S. Bankey, G.G Tapadlya, S.S Saboo, S. Bindaiya, Simultaneous determination of Rosuvastatin, Hydrochlorothiazide and Aspirin by Spectrophotometry, Int. J. of Chem tech research., 2012, Vol-1, P.No. 183-
- NamanDoshi, AvaniSheth, Tejas PaRSC, J B Dave and CN PaRSC., Spectrophotometric absorption factor method development and validation for estimation of RosuvastatinCacium and Aspirin in solid dosage forms., Journal of Chemical and Pharmaceutical Research, 2010, 2(3), P.No. 15-24.
- Suhas S. Agey, Ashok Peepliwal, Simultaneous estimation of Aspirin& Amlodipine in bulk and tablets by UV and RP-HPLC Method., Journal of Advances in Pharmacy and Healthcare Research.,2011, V-1,7 P.No. 67-73.
- Priyanka R Patil, Sachin U Rakesh, Pandurang., Simultaneous estimation of Rosuvastatin and Amlodipin by UV Spectrophotometric method, Reach J. of Pharm and Tech., April-June 2009, 2(2).P.No. 304-307.
- Thamake SL, Jadhav SD, Development and validation of method for simultaneous estimation of Atorvastatin calcium and Rosuvastatin from capsule dosage form by Order derivative spectroscopy, Asian J. Research Chem, 2009, 2(1), P.No.52-53.
- Vrushali Tambe, Vijayavichare, Ujjawala Kandekar and Shashikant dhole, Novel UV Spectrophotometric methods for estimation of Rosuvastatin and Hydrochlorothiazide by simultaneous equation and area under curve method. International Journal of Applied Pharmaceutics, 2010, V- 2, P.No. 20-22.
How to Cite This Article
Vancouver
Kumaraswamy G, Lalitha R, Vijayaprakash K. Validated spectrophotometric method for simultaneous estimation of rosuvastatin calcium and aspirin in tablet dosage forms [Internet]. Int J Pharm Chem Anal. 2016 [cited 2025 Oct 17];3(2):90-98. Available from: https://doi.org/
APA
Kumaraswamy, G., Lalitha, R., Vijayaprakash, K. (2016). Validated spectrophotometric method for simultaneous estimation of rosuvastatin calcium and aspirin in tablet dosage forms. Int J Pharm Chem Anal, 3(2), 90-98. https://doi.org/
MLA
Kumaraswamy, Gandla, Lalitha, Repeudi, Vijayaprakash, K.. "Validated spectrophotometric method for simultaneous estimation of rosuvastatin calcium and aspirin in tablet dosage forms." Int J Pharm Chem Anal, vol. 3, no. 2, 2016, pp. 90-98. https://doi.org/
Chicago
Kumaraswamy, G., Lalitha, R., Vijayaprakash, K.. "Validated spectrophotometric method for simultaneous estimation of rosuvastatin calcium and aspirin in tablet dosage forms." Int J Pharm Chem Anal 3, no. 2 (2016): 90-98. https://doi.org/