Print ISSN:-2394-2789

Online ISSN:-2394-2797

CODEN : IJPCN9

Article History

Received : 26-04-2021

Accepted : 29-04-2021

Available online : 11-08-2021



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Development of gastroretentiv floating tablets of losartan potassium by sublimation method


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Original Article

Author Details : Hiral S Bhusara*, Ara T Patel, Mayuree D Patel

Volume : 8, Issue : 2, Year : 2021

Article Page : 66-74

https://doi.org/10.18231/j.ijpca.2021.014



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Abstract

The purpose of present study was to formulate and Evaluate Sustained release floating tablet of losartan Potassium using Camphor and Polyethylene Oxide as Pore formation for floating and release retarding agent respectively to improve gastric residence time and patient compliance in management of hypertension. The tablet was prepared by direct compression by using HPMC K4 as dry binder. Camphor and PEO as floating and release retarding agent for sustained release floating tablet. Post compression was done to increase the hardness and floating time of tablet. Release modifier was used to speed up the release of drug from sustained release floating tablet. The effect of two independent variables like amount of Sublimating agent (camphor) and amount of Polyethylene oxide (PEO) on Q30min, Q360min, and Q720min was optimized using 32 factorial design and analyzed using the software design expert 10.0.3. The observed (actual values) responses were coincided well with the predicted values, given by the optimization technique. The floating tablet were characterized by FTIR for drug excipient compatibility.


Keywords: Losartan Potassium, Polyethylene Oxide (PEO), Camphor pore, Floating tablet



How to cite : Bhusara H S, Patel A T, Patel M D, Development of gastroretentiv floating tablets of losartan potassium by sublimation method. Int J Pharm Chem Anal 2021;8(2):66-74


Copyright © 2021 by author(s) and Int J Pharm Chem Anal. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (creativecommons.org)







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